I don’t see any reason not to, at present. I don’t necessarily believe in, say, supernatural entities, but I’m more concerned with origin, what exists beyond our universe, the nature of consciousness, etc. I believe a lot of that is simply outside of our abilities to fully understand as humans.

Take a 4th spatial dimension as a simple example. We can do all the work on understanding how one would work mathematically. We can even get something approaching an intuition about how things would move and work in a 4th dimension, but we’re simply not equipped to see, experience, interact with this 4th dimension. Another easy example of an unknowable is the thoughts and mental state of another. We can make inferences, we can ask, and we can trust that the information we get from those sources is accurate, but there’s no way to verify.

This same thing, the fundamentally unknowable, exists pretty much everywhere if you dig deep enough. I like to think of this relationship with unknowables as “spirituality”. Understanding that there are simply things that I cannot grasp, and being okay with that forms the basis for my spiritual worldview.

As stated before, as well, I believe this is all DEEPLY personal. I doubt any two people will ever arrive at the exact same conclusions. The thing with unknowables is there’s no way to really be “right” short of following your intuition, so as long as your personal beliefs don’t start impacting the will and agency of others, you do you.