For early and mid game I like semi organized spaghetti For each factory you designate a rectangle with a somewhat future proof size. Each rectangle should be at least 10 grid cells apart (F5 helps). So now your factory can grow in any direction unlike a main bus, is a lot quicker to build unlike strict city blocks (which are better for late game tho) and you still won’t have that much spaghetti because you have 10 grid cell wide corridors to route your belts. Sometimes 10 might not be enough tho, my belts next to red circuits became a real spaghetti :P