If we knew how to create world simulation, and how to make it working 4D, then humans would be able to plug themselves in, and experience 4D space. Alternatively there could simulated 4D beings, whose sentience could be transferred to robot body in our real 3D space.
That’s what interact with means: navigate, orient, decide, etc.
There’s nothing about our neural architecture that has “3D” built into the information it can process.
I disagree. I think we are very much hardwired to innately understand 3d space in an intuitive level. All else about higher and lower dimensions is learned experientially and/or academically, and it’s near impossible not to understand it in terms that relate to 3 dimensions or math. I also think that thinking about 4 dimensions in relation to 3 dimensions makes it impossible to truly understand 4 dimensional space as a whole. We can describe every detail of it mathematically, but still not be able to visualize it in whole. Regardless, given the fact that there is no 4th spatial dimension, I doubt either of us will ever have a definitive answer.