Been playing Warframe on Linux since 2020 when I made the switch, used to be you had to use a specific launch flag to make the game have audio and either plug in a controller or fake having one or the game would crash after around 5min. Thankfully such tweaks haven’t been necessary for years now and nowadays Warframe (and most games) just work. Things have gotten so good I rarely even check protonDB for compatibility before buying a game now!