I run GrapheneOS without any Google Play Services. I don’t want to be locked into any software and I selfhost all my backups except having encrypted backups in one cloud provider for very important things to keep them off-site.

Most of the things people generally would consider drawbacks like lack of google assistant, chrome, play store, youtube etc. I consider to be a positive thing. I am in mostly full control of permissions and I have a siloed work user when I do need to access Slack and other apps for company use.