Maybe a different religion, or especially political beliefs seems to be a big deal-breaker. Do you still find it worthwhile to keep them in your life?
I do. I have e.g. Christian Conservative friends, and Atheist Liberal ones, etc. I enjoy each one for what they are. I mean, nobody is perfect! (like me 😁)
We can disagree about pizza toppings, not that certain people don’t deserve rights. Get the fuck out of my life if you’re that type of asshole.